By Jon Trister, MD
Mechanical stresses are critical for control of tissue form and function
Mechanoresponsiveness is a fundamental feature of all living systems
Mechanical stress can directly alter many cellular processes, including signal transduction, gene expression, growth, differentiation and survival
Living organisms are constructed from tires of systems within a system within a system
A limb is composed of several organs: (bones, cartilages, ligaments, tendons, muscles, blood vessels, nerves)
Organs are constructed from tissues (muscles fibers,vascular endothelium,connective tissue), which are composed of groups of living cells and their associated Extracellular Matrix
Mechanosensetivity of the body is related to material properties of its components and to the architectural arrangement of its microstructure
Musculoskeletal system is an integrated framework which support the weight of our body, allows us to rapidly adjust to resist external forces, and permits us to move freely in our environment.
Selective pressures demand that the construction of such a machine minimizes mass without compromising its structural integrity to handle unexpected forces
Pre-stress and mechanotransduction are an important prerequisite to normal function of the living systems.
Tensegrity structures are characterized by use of continuous tension and local compression
Architecture, pre-stress and triangulation play the most critical role in the mechanical stability of living systems
Tensegrity network optimizes structural efficiency
Mechanical stresses applied at the macroscale result in structural rearrangement at the cellular and molecular level
Mechanical stress is concentrated and focused on signal transducing structures: Microfilaments, Integrins, Cytoskeleton ECM and Nucleus
Biotensegrity is a structural arrangement of the biological systems.
It is self-regulating process utilizing a specific pattern of interactions between members (organs, tissues, cells,organells, and other cellular structures etc) of the biological system (organism) to maintain life.
Mechanotransduction, Biochemical, Hormonal Neural,Humoral, Electromagnetic fields interactions, Gravitational force, Quantum entanglements and other known and unknown yet factors are the major mechanisms responsible for cell membrane regulation and transmission of information to and from the nucleus.
These processes modulate gene expression and induce biochemical, neuro-humoral, neuro-endocrine, emotional, electromagnetic and other possible responses.
This post was influenced by studying works of B.Fuller,D.Bohm,T.Kuhn, D.Ingber, S.Levine.