By Jon Trister, MD
Mechanical stresses are critical for control of tissue form and function
Mechanoresponsiveness is a fundamental feature of all living systems
Mechanical stress can directly alter many cellular processes, including signal transduction, gene expression, growth, differentiation and survival
Living organisms are constructed from tires of systems within a system within a system
A limb is composed of several organs: (bones, cartilages, ligaments, tendons, muscles, blood vessels, nerves)
Organs are constructed from tissues (muscles fibers,vascular endothelium,connective tissue), which are composed of groups of living cells and their associated Extracellular Matrix
Mechanosensetivity of the body is related to material properties of its components and to the architectural arrangement of its microstructure
Musculoskeletal system is an integrated framework which support the weight of our body, allows us to rapidly adjust to resist external forces, and permits us to move freely in our environment.
Selective pressures demand that the construction of such a machine minimizes mass without compromising its structural integrity to handle unexpected forces
Pre-stress and mechanotransduction are an important prerequisite to normal function of the living systems.
Tensegrity structures are characterized by use of continuous tension and local compression
Architecture, pre-stress and triangulation play the most critical role in the mechanical stability of living systems
Tensegrity network optimizes structural efficiency
Mechanical stresses applied at the macroscale result in structural rearrangement at the cellular and molecular level
Mechanical stress is concentrated and focused on signal transducing structures: Microfilaments, Integrins, Cytoskeleton ECM and Nucleus
Biotensegrity is a structural arrangement of the biological systems.
It is self-regulating process utilizing a specific pattern of interactions between members (organs, tissues, cells,organells, and other cellular structures etc) of the biological system (organism) to maintain life.
Mechanotransduction, Biochemical, Hormonal Neural,Humoral, Electromagnetic fields interactions, Gravitational force, Quantum entanglements and other known and unknown yet factors are the major mechanisms responsible for cell membrane regulation and transmission of information to and from the nucleus.
These processes modulate gene expression and induce biochemical, neuro-humoral, neuro-endocrine, emotional, electromagnetic and other possible responses.Cellular components of the organs and tissues, vascular and neurological structures, are influenced by microbiome.Microbiota are “ecological communities of commensal, symbiotic and pathogenic microorganisms” found in and on all multicellular organisms. Microbiota includes bacteria, archaea, protists, fungi and viruses. Microbiota have been found to be crucial for immunologic, hormonal and metabolic homeostasis of their host. The synonymous term microbiome describes either the collective genomes of the microorganisms that reside in an environmental niche or the microorganisms themselves
Microbiome persist in nearly every human body site, including tissue and blood. The genomes of these microbes continually interact with the human genome in order to regulate host metabolism.
Many components of this microbiome are capable of both commensal and pathogenic activity. They are additionally able to persist in both “acute” and chronic forms. Inflammatory conditions historically studied separately (autoimmune, neurological and malignant) are now repeatedly tied to a common trend: imbalance or dysbiosis of these microbial ecosystems.
Collective activity of the microbiome that drives inflammatory processes via complex microbe-microbe and host-microbe interactions. Many microbes survive as polymicrobial entities in order to evade the immune response. Pathogens in these communities alter their gene expression in ways that promote community-wide virulence. Other microbes persist inside the cells of the immune system, where they directly interfere with host transcription, translation, and DNA repair mechanisms. The numerous proteins and metabolites expressed by these pathogens further dysregulate human gene expression in a manner that promotes imbalance and immunosuppression. Molecular mimicry, or homology between host and microbial proteins, complicates the nature of this interference. When taken together, these microbe-microbe and host-microbe interactions are capable of driving the large-scale failure of human metabolism characteristic of many different inflammatory conditions.
This post was influenced by studying works of B.Fuller,D.Bohm,T.Kuhn, D.Ingber, S.Levine. A.Proal